Keywords
propofol dose
MR examination
How to Cite
Abstract
Abstract
Introduction; MRI examination is a standard procedure requested by physicians of neurologic sciences, for the patient with neurocognitive disorders. Propofol sedation was performed for this examination, and we had the suspicion that children with autism spectrum syndrome (AUT) required higher propofol dose than normal children.
Materials and methods. During a six years period, the first group of 30 autistic patients aged 3 to 10 years, received propofol infusion for brain MR, the control group of 30 normal patients with the same age, and the same mid-time of examination MR was also performed.
Results. 17 children of AUT group received 3±1 additional doses of propofol, 12 of them had to repeat MR sequences (adequate anesthesia) and the total dose of propofol 4,5 vs 3,6 compare to non-autistic children. Even and the recovery time is a little bit faster compared to the second group.
Conclusion: Autistic patients require more propofol dose to achieve a desirable level of anesthesia. All anesthesiologists should be aware in such patients with mental disorders when using propofol anesthesia.
References
Autism Spectrum Disorder - NIMH – NIH www.nimh.nih.gov › health › autism-spectrum-disorder
Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance Mohtashem Samsam, Raheleh Ahangari, and Saleh A NaserWorld J Gastroenterol. 2014 Aug 7; 20(29): 9942–9951. Published online 2014 Aug 7. doi: 10.3748/wjg.v20.i29.9942
Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder Elisa C. Walsh Johanna M. Lee1 Front. Syst. Neurosci., 22 June 2018 |
Eliez S, Reiss AL 2000 MRI neuroimaging of childhood psychiatric disorders: a selective review. J Child Psychol Psychiatry 41: 679–694
Sury MR, Smith JH. Deep sedation and minimal anesthesia. Paediatr Anaesth 2008; 18: 18 – 24
Krauss B, Green SM. Sedation and analgesia for procedures in children. N Engl J Med 2000; 342: 938 –45
Wakasugi M, Hirota K, Roth SH, Ito Y. the effects of general anesthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vivo. Anesth Analg 1999; 88:676-680
Westphalen rI, Hemmings HC Jr. Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals. J Pharmacol Exp ther 2003; 304:1188-1196
American Academy of Pediatrics; American Academy of Pediatric Dentistry, Cote CJ, Wilson S; Work Group on Sedation. Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: an update. Pediatrics 2006; 118: 2587-602.
Yu ZY, Wang W, Fritschy JM, Witte OW, redecker C. Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brain res 2006; 1099:73-81.
Ma DQ, Whitehead PL, Menold MM, Martin Er, Ashley- Koch AE, Mei H et al. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet 2005; 77:377- 388.
Shinohe A, Hashimoto K, Nakamura K, tujii M, Iwata Y, Tsuchiya KJ et al. Increased serum levels of glutamate in adult patients with autism. Prog Neuropsychopharmacol,Biol Psychiatry 2006; 30:1472-1477.
Gomot M, Giard MH, Adrien JL, Barthelemy C, Bruneau N. Hypersensitivity to acoustic change in children with autism: electrophysiological evidence of left frontal cortex dysfunctioning. Psychophysiology 2002; 39:577-584
Submission of a manuscript implies that the submitted work has not been published before (except as part of a thesis or report, or abstract); that it is not under consideration for publication elsewhere; that its publication has been approved by all co-authors. If and when the manuscript is accepted for publication, the author(s) still hold the copyright and retain publishing rights without restrictions. Authors or others are allowed to multiply article as long as not for commercial purposes. For the new invention, authors are suggested to manage its patent before published. The license type is (CC BY-NC 4.0)